| Pair Name | Gambogenic acid, Doxorubicin | ||
| Phytochemical Name | Gambogenic acid (PubChem CID: 10794070 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gambogenic acid, Doxorubicin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | MAP1LC3A | hsa84557 | |
| Down-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | BECN1 | hsa8678 | |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | BEL-7402 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_5492 |
| Result | Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. | |||
| No. | Title | Href |
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| 1 | Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biol Pharm Bull. 2022;45(1):63-70. doi: 10.1248/bpb.b21-00511. | Click |
